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03303.txt
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1994-01-17
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$Unique_ID{BRK03303}
$Pretitle{}
$Title{probucol}
$Subject{Lorelco Merrell Dow Antihyperlipidemic lipid-lowering drug probucol
hypercholesterolemia high blood cholesterol decrease production}
$Volume{}
$Log{}
Copyright (C) 1993 Publications International, Ltd.
probucol
------------------------------------------------------------------------------
BRAND NAME (Manufacturer)
Lorelco (Merrell Dow)
TYPE OF DRUG
Antihyperlipidemic (lipid-lowering drug)
INGREDIENT
probucol
DOSAGE FORM
Tablets (250 mg and 500 mg)
STORAGE
Probucol should be stored at room temperature in a tightly closed,
light-resistant container.
USES
This medication is used to treat hypercholesterolemia (high blood
cholesterol levels) in patients who have not responded to diet, weight
reduction, exercise, and control of blood sugar. It is not clear how probucol
lowers blood cholesterol levels, but it is thought to decrease the body's own
production of cholesterol.
TREATMENT
Probucol should be taken with meals, in order to maximize its
effectiveness.
If you miss a dose of this medication, take the missed dose as soon as
possible, unless it is almost time for the next dose. In that case, do not
take the missed dose at all; just return to your regular dosing schedule. Do
not double the next dose.
The therapeutic benefits of this medication may not become apparent for
up to three months after you begin therapy with this drug.
SIDE EFFECTS
Minor.
Diarrhea, dizziness, gas, headache, insomnia, nausea, stomach upset, or
vomiting. These side effects should disappear as your body adjusts to the
medication.
If you feel dizzy, sit or lie down for a while; get up slowly from a
sitting or reclining position, and be careful on stairs. Take special care
when operating an automobile or potentially dangerous equipment.
Major.
Tell your doctor about any side effects that are persistent or
particularly bothersome. IT IS ESPECIALLY IMPORTANT TO TELL YOUR DOCTOR about
blurred vision; bloody or black, tarry stools; chest pain; impotence;
palpitations; rash; ringing in the ears; sweating; tingling sensations; or
unusual bleeding or bruising.
INTERACTIONS
The effectiveness of chenodiol, used to treat gallstone disease, could
possibly be decreased by concurrent probucol therapy.
Before starting to take probucol, BE SURE TO TELL YOUR DOCTOR about any
medications you are currently taking, especially chenodiol.
WARNINGS
* Tell your doctor about unusual or allergic reactions you may have had
to any medications, especially to probucol.
* Before starting this medication, be sure to tell your doctor if you now
have or have ever had biliary tract disorders, gallstones or gallbladder
disease, heart disease, or liver disease.
* Do not stop taking this medication unless you first check with your
doctor. Stopping the medication abruptly may lead to a rapid increase in
blood lipid (fats) and cholesterol levels. Your doctor may want to start you
on a special diet or another medication when probucol treatment is stopped.
* Be sure to tell your doctor if you are pregnant. Although probucol
appears to be safe during pregnancy, extensive studies in humans have not been
conducted. If you and your doctor decide that you should stop the medication
for a planned pregnancy, some form of birth control should be used for at
least six months after probucol therapy is stopped to ensure that the
medication has been completely eliminated from the body. Also, tell your
doctor if you are breast-feeding an infant. It is not known whether probucol
passes into breast milk.
----------------
The material contained here is "FOR INFORMATION ONLY" and should not replace
the counsel and advice of your personal physician. Promptly consulting your
doctor is the best path to a quick and successful resolution of any medical
problem.